Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells.
P.aeruginosa is an opportunistic pathogen that chronically infects the lungs of 85% of adult patients with Cystic Fibrosis (CF).Previously, we demonstrated that P.aeruginosa reduced wt-CFTR Cl secretion by airway epithelial cells.Recently, a new investigational drug VX-809 has been shown to increase F508del-CFTR Cl secretion in human bronchial epit